Saturday, April 20, 2013

Second Hint Posted For 2013 'Rockstar Energy Drink Uproar ...

The second hint has been released for the lineup to this years ?Rockstar Energy Drink Uproar Festival?. While the first clue was quite clearly Alice In Chains, the latest picture posted is a bit more obtuse.

The current consensus appears to have fans guessing that the number of hats being off heads is a nod to Chevelle and the title of their latest album, ?Hats Off To The Bull?. Dates for the tour were revealed earlier this week. The lineup for the tour will officially be announced this coming Monday, April 22nd.

Source: http://www.theprp.com/2013/04/19/news/second-hint-posted-for-2013-rockstar-energy-drink-uproar-festival/

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Tuesday, April 16, 2013

Alan Gordon Apologizes For Gay Slur, Will Johnson Responds With Game-Winning Goal (VIDEO)

PORTLAND, Ore. -- After Earthquakes forward Alan Gordon directed a slur at Will Johnson, the Timbers midfielder responded with the game-winning goal.

Johnson's goal on a free kick in the 78th minute gave Portland a 1-0 win on Sunday night. It was the Timbers' second straight victory, moving the team to 2-1-3 under new coach Caleb Porter.

Gordon was ejected in the second half after receiving a pair of yellow cards involving fouls on other players. But minutes earlier, he was seen on the television broadcast using a slur toward Johnson.

After the match, Gordon released a statement through the team.

"I would like to sincerely apologize to everyone who watched tonight's match on NBC Sports Network. The language I used came during a heated moment and does not reflect my feelings toward the gay and lesbian community. I made a mistake and I accept full responsibility for my actions," the statement read.

Johnson was diplomatic.

"I think it's probably better that I don't comment on that," he said. "It's a very sensitive matter. I'd prefer the league go through with their protocol."

It's standard procedure for Major League Soccer to review the video of matches that involve a red card.

Gordon was escorted from the locker room after the game by team personnel and did not speak with reporters after match.

The loss dropped the Earthquakes to 2-3-2.

Forward Steven Lenhart was back in San Jose's starting lineup after returning from a partially torn meniscus last weekend as a reserve. The striker missed San Jose's first five matches after offseason surgery. That meant the Earthquakes' so-called Bash Brothers ? Lenhart and Gordon ? were both starting for the first time this season.

But Gordon was sent off in the 68th minute after getting a second yellow card, for elbowing Timbers defender Mikael Silvestre in the face, causing a bloody lip. Gordon was also received a yellow in the 41st minute for a foul on Diego Chara.

Video replay appeared to show that Gordon directed a slur at Johnson a few minutes before his ejection. Such a comment would bring an automatic three-match suspension by MLS.

Some 10 minutes later, Johnson hit a free kick from just outside the penalty arc that sailed over the wall and past goalkeeper Jon Busch.

"It doesn't work every time," Johnson said. "But when it does, it's nice."

Earlier in the day, Porter had texted Johnson asking, "Why don't you hit a free kick tonight?" The coach was floored when it happened.

"Everybody's going to talk about the free kick," Johnson said. "But it's really about the team."

The teams played to a scoreless draw in the first half. Portland missed an opportunity when Ryan Johnson's header was snagged in midair by Busch in the 43rd minute.

The Timbers dominated possession (62.6 percent) in the first half, but matched San Jose with just four shots. It was a physical match, as evidenced by the yellow cards. Four minutes after Chara was fouled by Gordon, Chara got a yellow card for a foul on Rafael Baca.

Following the game, Yallop questioned why officials waited to make the call to eject Gordon until after the video scoreboard had shown a replay, firing up the crowd at Jeld-Wen.

"You should let the officials call the game," he said, adding that he had not seen the replay.

Portland was without midfielder Diego Valeri, who was elbowed in the face last weekend against the Dynamo and only participated in light workouts this week because of the league's concussion protocol. The Timbers also lost defender David Horst to a fractured right tibia during the Houston game. He is out six months.

The Timbers also announced shortly before the game that defender Andrew Jean-Baptiste would not start because of a right adductor strain. Futty Danso started in his place.

Portland is 2-0-4 against the Earthquakes. Sunday's game was the first of a home-and-home with San Jose, and the two teams meet again next Sunday at Buck Shaw Stadium.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/04/15/alan-gordon-gay-slur-will-johnson-goal_n_3083715.html

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Saturday, April 13, 2013

Blocking immune response protein helps body clear chronic infection; Potential therapy for HIV, other viral infections?

Apr. 11, 2013 ? UCLA scientists have shown that temporarily blocking a protein critical to immune response actually helps the body clear itself of chronic infection. Published in the April 12 edition of Science, the finding suggests new approaches to treating persistent viral infections like HIV and hepatitis C.

The research team studied type-1 interferons (IFN-1), proteins released by cells in response to disease-causing organisms that enable cells to talk to each other and orchestrate an immune response against infection. Constant IFN-1 signaling is also a trademark of chronic viral infection and disease progression, particularly in HIV.

"When cells confront viruses, they produce type-1 interferons, which trigger the immune system's protective defenses and sets off an alarm to notify surrounding cells," explained principal investigator David Brooks, assistant professor of microbiology, immunology and molecular genetics at UCLA's David Geffen School of Medicine and College of Letters and Sciences. "Type-1 interferon is like the guy in the watch tower yelling, 'red alert,' when the marauders try to raid the castle."

Scientists have long viewed IDF-1 as beneficial, because it stimulates antiviral immunity and helps control acute infection. Blocking IDF-1 activity, they reasoned, would allow infection to run rampant through the immune system.

On the other hand, prolonged IFN-1 signaling is linked to many chronic immune problems. The research team wondered whether obstructing the signaling pathway would enable the immune system to recover enough to fight off chronic infection.

To test this theory, Brooks and his colleagues injected mice suffering from chronic viral infection with an antibody that temporarily blocked IFN-1 activity.

Much to their surprise, they discovered that giving the immune system a holiday from IFN-1 boosted the body's ability to fight the virus. Stunningly, the respite also reversed many of the immune problems that result from chronic infection, such as a rise in proteins that suppress immune response, continuous activation of the immune system and disruption of lymph tissue.

The findings fly in the face of past studies that suggest eliminating IFN-1 activity in mice leads to severe, life-long infection.

"What we saw was entirely illogical," admitted Brooks. "We'd blocked something critical for infection control and expected the immune system to lose the fight against infection. Instead, the temporary break in IFN-1 signaling improved the immune system's ability to control infection. Our next task will be to figure out why and how to harness it for therapies to treat humans."

"We suspect that halting IFN-1 activity is like pushing the refresh button," said first author Elizabeth Wilson, a UCLA postdoctoral researcher. "It gives the immune system time to reprogram itself and control the infection."

Uncovering this mechanism could offer potential for new therapies to tackle viruses like HIV and hepatitis C, according to Brooks. The team's next step will be to pinpoint how to sustain IFN-1's control of the virus while blocking the negative impact that chronic IFN-1 activity wreaks on the immune system.

The National Institute of Allergy and Infectious Diseases and the UCLA Center for AIDS Research supported the research.

Brooks' coauthors included first author Elizabeth Wilson, Douglas Yamada, Heidi Elsaesser, Jonathan Herskovitz, Jane Deng and Genhong Cheng, all of UCLA; Bruce Aronow of the University of Cincinnati, and Christopher Karp of the University of Cincinnati and Bill and Melinda Gates Foundation.

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The above story is reprinted from materials provided by University of California, Los Angeles (UCLA), Health Sciences, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. E. B. Wilson, D. H. Yamada, H. Elsaesser, J. Herskovitz, J. Deng, G. Cheng, B. J. Aronow, C. L. Karp, D. G. Brooks. Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection. Science, 2013; 340 (6129): 202 DOI: 10.1126/science.1235208

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/KziwAhoigYM/130411142712.htm

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